Catalog No.: PC-35652Not For Human Use, Lab Use Only.
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
FR58P1a induces mitochondrial NADH oxidation, and Sirt1/AMPK-activation that in turn inhibits fibronectin-dependent migration of TNBC cells by decreasing β1-integrin at the cell surface.
FR58P1a activates AMPK in a Sirt1-dependent fashion, triggers metabolic adaptation but maintained the inhibitory effect of fibronectin-dependent migration in TNBC cells
