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Chemical Structure : FR58P1a
Catalog No.: PC-35652Not For Human Use, Lab Use Only.
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
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FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
FR58P1a induces mitochondrial NADH oxidation, and Sirt1/AMPK-activation that in turn inhibits fibronectin-dependent migration of TNBC cells by decreasing β1-integrin at the cell surface.
FR58P1a activates AMPK in a Sirt1-dependent fashion, triggers metabolic adaptation but maintained the inhibitory effect of fibronectin-dependent migration in TNBC cells
| M.Wt | 477.395 | |
| Formula | C24H29BrO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Urra FA, et al. Sci Rep. 2018 Sep 4;8(1):13190.
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