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Chemical Structure : FR900359
Catalog No.: PC-22683Not For Human Use, Lab Use Only.
FR900359 is a plant-derived depsipeptide and specific pan-Gq (Gq/11/14) inhibitor, selectively inhibits Gq-dependent signalling, with little effect on Galphasbetagamma, Galphaibetagamma, or Galpha12/13betagamma heterotrimer activity.
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FR900359 is a plant-derived depsipeptide and specific pan-Gq (Gq/11/14) inhibitor, selectively inhibits Gq-dependent signalling, with little effect on Galphasbetagamma, Galphaibetagamma, or Galpha12/13betagamma heterotrimer activity.
FR900359 fully blocked Gq-mediated IP1 accumulation, did not perturb the cAMP-raising by Gs-sensitive prostanoid EP2/EP4 receptors or cAMP lowering by Gi-sensitive prostaglandin D2 receptor DP2/CRTH2.
FR900359 inhibits Gαq, Gα11 and Gα14, but not Gα16 or any other mammalian Gα isoform.
FR900359 does not impair G protein-independent β-arrestin recruitment. induces melanoma cells into differentiation and inhibits melanoma cell migration.
| M.Wt | 1002.17 | |
| Formula | C49H75N7O15 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schrage R, et al. Nat Commun. 2015 Dec 14;6:10156.
2. Carr R 3rd, et al. Mol Pharmacol. 2016 Jan;89(1):94-104.
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