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Chemical Structure : FR 901463
Catalog No.: PC-73146Not For Human Use, Lab Use Only.
FR 901463 is an anti-tumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663.
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FR 901463 is an anti-tumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663. FR901464 induced characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells.
FR901464 suppressed the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells.
| M.Wt | 544.082 | |
| Formula | C27H42ClNO8 | |
| Appearance | Solid | |
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1. Nakajima H, et al. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203.
2. Nakajima H, et al. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.
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