FR 901463

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Chemical Structure : FR 901463

Catalog No.: PC-73146Not For Human Use, Lab Use Only.

FR 901463 is an anti-tumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FR 901463 is an anti-tumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663. FR901464 induced characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells.
FR901464 suppressed the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells.

Physicochemical Properties

M.Wt	544.082
Formula	C27H42ClNO8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Chemical Name/SMILES

References

1. Nakajima H, et al. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203.

2. Nakajima H, et al. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

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FR 901463

Biological Activity

Physicochemical Properties

References

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