FSHR agonist 21f

Chemical Structure : FSHR agonist 21f

Catalog No.: PC-20751Not For Human Use, Lab Use Only.

FSHR agonist 21f is a small molecule allosteric agonist of follicle stimulating hormone receptor (FSHR) with high affinity and activation efficacy (pEC50=7.72).

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Biological Activity

FSHR agonist 21f is a small molecule allosteric agonist of follicle stimulating hormone receptor (FSHR) with high affinity and activation efficacy (pEC50=7.72).
FSHR agonist 21f can activate FSHR, LHCGR and TSHR with high potency and efficacy, while the activation potency for FSHR is more than 10-fold higher than LHCGR and TSHR.

Physicochemical Properties

M.Wt	467.63
Formula	C26H33N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=NC(C2=CC=CS2)=C3N1CCC4=C3C=C(OC(C)C)C(OC)=C4)N(C(C)(C)C)CC

References

1. Duan J, et al. Nat Commun. 2023 Jan 31;14(1):519.

2. Patent WO2010136438A1

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FSHR agonist 21f

Biological Activity

Physicochemical Properties

References

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