FT-001 |CAS:1778655-51-8 Probechem Biochemicals

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Chemical Structure : FT-001

FT-001 (FT001, FT 001)

Catalog No.: PC-61740Not For Human Use, Lab Use Only.

FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1.

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Biological Activity

FT-001 (FT001) is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1.
FT-001 inhibits the expression of MYC in the MV-4-11 cell line with IC50 of 0.46 uM, shows anti-proliferative activity with IC50 of 0.22 uM.
FT-001 displays complete tumor growth inhibition in mouse MV-4-11 xenograft model.

Physicochemical Properties

M.Wt	467.584
Formula	C25H29N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-(cyclopropanecarbonyl)-6-(4-(1,1-dioxidothiomorpholino)phenyl)-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one

References

1. Millan DS, et al. ACS Med Chem Lett. 2017 Jul 14;8(8):847-852.

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FT-001 (FT001, FT 001)

Biological Activity

Physicochemical Properties

References

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