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Chemical Structure : FT-671
CAS No.: 1959551-26-8
Catalog No.: PC-60088Not For Human Use, Lab Use Only.
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
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|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
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FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
FT-671 inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
FT-671 destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21.
FT-671 blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.
| M.Wt | 533.488 | |
| Formula | C24H23F4N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
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1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
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