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FT385

Chemical Structure : FT385

CAS No.:

FT385 (FT3967385)

Catalog No.: PC-72253Not For Human Use, Lab Use Only.

FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM.

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Biological Activity

FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM.
FT385 (FT3967385) displays high selectivity against a broad panel of USP enzymes, with one exception of plasma membrane-associated USP6.
FT385 engages USP30 in cells at low nanomolar concentrations.
Inhibition of USP30 via FT385 phenocopies USP30 KO in enhancing basal mitophagy and promoting ubiquitylation of TOM20 upon depolarisation, enhances phospho-Ser65 ubiquitin (pUb) levels on mitochondria of SHSY5Y cells.

Physicochemical Properties

M.Wt 373.416
Formula C21H19N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(1-cyanopyrrolidin-3-yl)-3-(2-phenoxyphenyl)-1H-pyrazole-5-carboxamide

References

1. Emma V Rusilowicz-Jones, et al. Life Sci Alliance. 2020 Jul 7;3(8):e202000768.

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