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Chemical Structure : FTX-6746
Catalog No.: PC-20679Not For Human Use, Lab Use Only.
FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.
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FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.
FTX-6746 exhibits potent in vitro growth inhibition preferentially in cell lines with activated PPARG signaling.
FTX-6746 (3, 10, 30 and 60 mg/kg, twice daily, oral) demonstrated tumor growth inhibition or regression in UMUC9 xenograft tumors.
| M.Wt | 316.69 | |
| Formula | C16H7ClF2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. J. Mertz, et al. European Journal of Cancer. 6 OCTOBER 2022 12:00–20:00: POSTER SESSION: NEW DRUGS
2. Patent WO2022187203 A1.
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