Catalog No.: PC-20679Not For Human Use, Lab Use Only.
FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.
FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA.
FTX-6746 exhibits potent in vitro growth inhibition preferentially in cell lines with activated PPARG signaling.
FTX-6746 (3, 10, 30 and 60 mg/kg, twice daily, oral) demonstrated tumor growth inhibition or regression in UMUC9 xenograft tumors.
