Chemical Structure : FZ581
CAS No.:
FZ581
(FZ-581)
Catalog No.: PC-27819Not For Human Use, Lab Use Only.
FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL).
FZ581 shows high selectivity over the soluble epoxide hydrolase activity (sEH-H).
FZ581 does not exhibit significant binding toward other 9 tested phosphatases, as well as COX-1 and COX-2, lipid phosphate phosphatases (LPPs) LPP1-3.
FZ581 exhibits inhibitory activity across different species in vitro.
FZ581 shows dose-dependent inhibition of 1-oleyl monoacyl glycerol (sn1-18:1 MAG) formation through inhibition of recombinant mouse sEH.
FZ581 (1 mg/kg) demonstrated a significant increase of main sEH-P substrate levels without affecting plasma levels of sEH-H substrates in mice and rats.
Physicochemical Properties
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M.Wt
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466.67
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Formula
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C14H12ClIN2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-chloro-2-((4-iodo-3-methylphenyl)amino)-5-sulfamoylbenzoic acid
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References
1. Zhu WF, et al. ACS Chem Biol. 2026 Aug 21;21(8):2053-2067.
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