Factor D inhibitor 6 |CAS:1386455-51-1 Probechem Biochemicals

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Chemical Structure : Factor D inhibitor 6

Factor D inhibitor 6

Catalog No.: PC-62226Not For Human Use, Lab Use Only.

Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.
Factor D inhibitor 6 is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 6 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.

Physicochemical Properties

M.Wt	484.916
Formula	C23H22ClFN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

References

1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110.

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