Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM.
Factor D inhibitor 7 is highly selective for human FD, showing no inhibition of factor B.
Factor D inhibitor 7 efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 7 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.
