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Fadeucravacitinib

Chemical Structure : Fadeucravacitinib

CAS No.: 2704587-24-4

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Fadeucravacitinib (ICP-488, ICP488)

Catalog No.: PC-27425Not For Human Use, Lab Use Only.

Fadeucravacitinib (ICP-488) is a potent and selective, allosteric TYK2 inhibitor with IC50 of 5.7 nM for TYK2-JH2, blocks the signal transduction of IL-23, IL-12, type 1 IFN and other inflammatory cytokine, thereby inhibiting the pathological process of autoimmune and inflammatory diseases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Fadeucravacitinib (ICP-488) is a potent and selective, allosteric TYK2 inhibitor with IC50 of 5.7 nM for TYK2-JH2, blocks the signal transduction of IL-23, IL-12, type 1 IFN and other inflammatory cytokine, thereby inhibiting the pathological process of autoimmune and inflammatory diseases.

    Physicochemical Properties

    M.Wt 425.47
    Formula C20H19D3N8O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-Pyridazinecarboxamide, 6-[(cyclopropylcarbonyl)amino]-4-[[2-(methoxy-d3)-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino]-N-methyl-

    References

    1. Patent WO2021180072 A1 2021-09-16.

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