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Farudodstat

Chemical Structure : Farudodstat

CAS No.: 1035688-66-4

Farudodstat (ASLAN003, LAS186323)

Catalog No.: PC-38392Not For Human Use, Lab Use Only.

Farudodstat (ASLAN003) is a highly potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 35 nM (human DHODH), significantly inhibits protein synthesis via activation AP-1 transcription, induces cell differentiation of AML cell lines.

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Biological Activity

Farudodstat (ASLAN003) is a highly potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 35 nM (human DHODH), significantly inhibits protein synthesis via activation AP-1 transcription, induces cell differentiation of AML cell lines.
Farudodstat (ASLAN003) inhibit leukemic cell proliferation of THP-1, MOLM-14 and KG-1 with IC50 values of 152 nM, 582 nM, and 382 nM, respectively.
Farudodstat (ASLAN003) decreases viability and induces differentiation in primary AML blasts and myelodysplastic syndrome samples, triggers apoptotic pathways via both mitochondrial and death receptor pathways.
Farudodstat (ASLAN003) (50 mg/kg, once daily oral gavage) demonstrates robust in vivo efficacy in multiple mouse xenograft AMLs.

Physicochemical Properties

M.Wt 356.329
Formula C19H14F2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid

References

1. Jianbiao Zhou, et al. Haematologica. 2020 Sep 1;105(9):2286-2297.

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