Chemical Structure : Fascin inhibitor G2
CAS No.:
1569076-11-4
Fascin inhibitor G2
Catalog No.: PC-24547Not For Human Use, Lab Use Only.
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization.
G2 inhibited the actin-bundling activity of fascin, but has no inhibitory effect on actin polymerization itself and the actin-bundling activity of L-plastin.
G2 directly interact with fascin with Kd of 5-20 uM.
G2 inhibits fascin function in cells and impairs the filopodial formation.
G2 could inhibit breast tumour cell migration specifically, with no effect on the growth of MDA-MB-231 and 4T1 tumour cells.
G2 is a potent inhibitor of 4T1 tumour cell metastasis from the mammary gland to the lungs, and the actin-bundling activity as well as filopodia are critical for tumour metastasis in mouse models.
Physicochemical Properties
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M.Wt
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385.35
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Formula
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C20H14F3N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide
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References
1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun. 2015;6:7465.
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