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Chemical Structure : Fatostatin
CAS No.: 125256-00-0
Catalog No.: PC-22262Not For Human Use, Lab Use Only.
Fatostatin is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | Get quote |
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Fatostatin is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells.
Fatostatin blocks the activation process of both isoforms of SREBP, SREBP1 and SREB2.
Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells.
Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain.
Fatostatin blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
| M.Wt | 294.42 | |
| Formula | C18H18N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole |
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1. Kamisuki S, et al. Chem Biol. 2009 Aug 28;16(8):882-92.
2. Li X, et al. Mol Cancer Ther. 2014 Apr;13(4):855-66.
3. Kamisuki S, et al. J Med Chem. 2011 Jul 14;54(13):4923-7.
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