Catalog No.: PC-22262Not For Human Use, Lab Use Only.
Fatostatin is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells.
Fatostatin is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. Fatostatin blocks the activation process of both isoforms of SREBP, SREBP1 and SREB2. Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain. Fatostatin blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
Physicochemical Properties
M.Wt
294.42
Formula
C18H18N2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole
References
1. Kamisuki S, et al. Chem Biol. 2009 Aug 28;16(8):882-92.
2. Li X, et al. Mol Cancer Ther. 2014 Apr;13(4):855-66.
3. Kamisuki S, et al. J Med Chem. 2011 Jul 14;54(13):4923-7.
