Filapixant | P2X3 antagonist | Probechem Biochemicals

Chemical Structure : Filapixant

Filapixant (BAY1902607, BAY 1902607)

Catalog No.: PC-20738Not For Human Use, Lab Use Only.

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Biological Activity

Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754).
Filapixant has a higher in vitro selectivity for P2X3 than other receptor antagonists such as gefapixant, or even eliapixant.

Physicochemical Properties

M.Wt	521.56
Formula	C24H26F3N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N[C@@H](C1=CN=C(C(F)(F)F)N=C1)C)C2=CC(C3=NC=C(C)S3)=CC(OC[C@H]4CN(C)CCO4)=C2

References

1. Davenport AJ, et, al. 1,3-thiazol-2-yl substituted benzamides. WO2016091776A1.

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Filapixant (BAY1902607, BAY 1902607)

Biological Activity

Physicochemical Properties

References

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