Chemical Structure : Flavopiridol
CAS No.:
146426-40-6
Flavopiridol
(L-868275, HMR-1275, Alvocidib, NSC 649890)
Catalog No. : PC-42049Not For Human Use, Lab Use Only.
Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4204901
Biological Activity
Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Physicochemical Properties
M.Wt
401.8402
Formula
C21H20ClNO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
References
1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A.
2. Carlson BA, et al. Cancer Res.
3. Senderowicz AM, et al. Invest New Drugs.
4. Kim KS, et al. J Med Chem.
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