Chemical Structure : Flavopiridol hydrochloride
CAS No.:
131740-09-5
Flavopiridol hydrochloride
(HL 275, NSC 649890, MDL 107826A, Alvocidib Hydrochloride)
Catalog No. : PC-42050Not For Human Use, Lab Use Only.
Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Packing Price Stock Quantity 10 mg $58 In stock 0 1 2 3 4 5 25 mg $98 In stock 0 1 2 3 4 5 50 mg $168 In stock 0 1 2 3 4 5 100 mg $268 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4205001
Biological Activity
Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDK s inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Physicochemical Properties
M.Wt
438.3011
Formula
C21H21Cl2NO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)
References
1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.
2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.
3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.
4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.
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