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Chemical Structure : Flavopiridol hydrochloride
CAS No.: 131740-09-5
Catalog No.: PC-42050Not For Human Use, Lab Use Only.
Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $168 | In stock | |
| 100 mg | $268 | In stock | |
| 250 mg | Get quote |
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Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Flavopiridol (Alvocidib) inhibits cell cycle progression in either G1 or G2 in human breast carcinoma cells, induces programmed cell death, promote differentiation, inhibits angiogenic processes and modulates transcriptional events.
| M.Wt | 438.3011 | |
| Formula | C21H21Cl2NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) |
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1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.
2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.
3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.
4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.
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