Catalog No.: PC-28171Not For Human Use, Lab Use Only.
Formononetin (Flavosil, Biochanin B, Formononetol) is a natural isoflavonoid with potential anti-angiogenic and anti-cancer activities, directly inhibits FGFR2 kinase activity with IC50 of 4.31 uM.
Formononetin (Flavosil, Biochanin B, Formononetol) is a natural isoflavonoid with potential anti-angiogenic and anti-cancer activities, directly inhibits FGFR2 kinase activity with IC50 of 4.31 uM.
Formononetin demonstrates inhibition of endothelial cell proliferation, migration, and tube formation in response to basic fibroblast growth factor 2 (FGF2).
Formononetin suppresses FGF2-induced microvessel sprouting of rat aortic rings and angiogenesis.
Formononetin suppresses FGF2-triggered activation of FGFR2 and protein kinase B (Akt) signaling.
Formononetin directly inhibits proliferation and blocked the oncogenic signaling pathways in breast cancer cell.
Formononetin shows growth-inhibitory activity associated with inhibition of tumor angiogenesis in xenograft models of breast cancer.
Formononetin prevents ovariectomy-induced bone loss in rats.
Formononetin also potently and preferentially inhibits the gamma-isozymes of mammalian alcohol dehydrogenase (gammagamma-ADH).
Physicochemical Properties
M.Wt
268.27
Formula
C16H12O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
References
1. Xiao Yu Wu, et al. Oncotarget. 2015 Dec 29;6(42):44563-78.
2. Ha H, et al. Arch Pharm Res. 2010 Apr;33(4):625-32.
3. Wong CK, et al. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):191-202.
