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Fosdagrocorat

Chemical Structure : Fosdagrocorat

CAS No.: 1044535-58-1

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Fosdagrocorat (PF-04171327, PF 04171327)

Catalog No.: PC-61849Not For Human Use, Lab Use Only.

Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat)..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Fosdagrocorat (PF-04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat).

    Physicochemical Properties

    M.Wt 574.537
    Formula C29H30F3N2O5P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate

    References

    1. Stock T, et al. Int J Rheum Dis. 2017 Aug;20(8):960-970.

    2. Miyoshi S, et al. Int J Clin Pharmacol Ther. 2016 Dec;54(12):966-976.

    3. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.

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