Fulzerasib (IBI351, GFH925) | KRAS G12C inhibitor

Chemical Structure : Fulzerasib

Catalog No.: PC-20037Not For Human Use, Lab Use Only.

Fulzerasib (IBI351, IBI-351) is a potent covalent and irreversible inhibitor of KRAS G12C.

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Biological Activity

Fulzerasib (IBI351, IBI-351, GFH925) is a potent covalent and irreversible inhibitor of KRAS G12C.

M.Wt	617.08
Formula	C32H30ClFN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aR)-3-acryloyl-11-chloro-10-(2-fluoro-6-hydroxyphenyl)-8-(2-isopropyl-4-methylpyridin-3-yl)-6-methyl-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione

1. Patent WO2021083167 A1