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Furosemide

Chemical Structure : Furosemide

CAS No.: 54-31-9

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Furosemide

Catalog No.: PC-24730Not For Human Use, Lab Use Only.

Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter NKCC1 and NKCC2, is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors.

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500 mg $29 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC, encoded by SLC12A1 and SLC12A2) cotransporter NKCC1 and NKCC2, is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors.

Physicochemical Properties

M.Wt 330.74
Formula C12H11ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid

References

1. C M Gillen, et al. J Biol Chem. 1996 Jul 5;271(27):16237-44.

2. S A Thompson, et al. Mol Pharmacol. 1999 Jun;55(6):993-9.

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