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Chemical Structure : G140
CAS No.: 2369751-07-3
Catalog No.: PC-73360Not For Human Use, Lab Use Only.
G140 is a potent, specific human cGAS small-molecule inhibitor with IC50 of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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G140 is a potent, specific human cGAS small-molecule inhibitor with IC50 of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
G140 showed dose-dependent inhibitory activity in THP1 cells with IC50 of 1.7 uM, as determined by qRT-PCR for IFNB1 mRNA.
G140 shows no off-target effect against other nucleotidyl transferase enzymes.
G140 inhibits the SEAP NF-κB pathway reporter with IC50 of 1.36 uM.
| M.Wt | 379.24 | |
| Formula | C17H16Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone |
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1. Lodoe Lama, et al. Nat Commun. 2019 May 21;10(1):2261.
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