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Chemical Structure : G140
Catalog No.: PC-73360Not For Human Use, Lab Use Only.
G140 is a potent, specific human cGAS small-molecule inhibitor with IC50 of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
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G140 is a potent, specific human cGAS small-molecule inhibitor with IC50 of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
G140 showed dose-dependent inhibitory activity in THP1 cells with IC50 of 1.7 uM, as determined by qRT-PCR for IFNB1 mRNA.
G140 shows no off-target effect against other nucleotidyl transferase enzymes.
G140 inhibits the SEAP NF-κB pathway reporter with IC50 of 1.36 uM.
| M.Wt | 379.24 | |
| Formula | C17H16Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lodoe Lama, et al. Nat Commun. 2019 May 21;10(1):2261.
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