GAA-4OH

Chemical Structure : GAA-4OH

Catalog No.: PC-26765Not For Human Use, Lab Use Only.

GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD.

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Biological Activity

Physicochemical Properties

M.Wt	517.71
Formula	C33H43NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,6E,10E)-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-N-(4-hydroxyphenyl)-2,6,10-trimethyltrideca-2,6,10-trienamide

References

1. Cevallos K, et al. J Med Chem. 2026 May 4. doi: 10.1021/acs.jmedchem.5c03686.

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GAA-4OH

Biological Activity

Physicochemical Properties

References

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