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GAT100

Chemical Structure : GAT100

CAS No.: 1663564-42-8

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GAT100 (GAT-100)

Catalog No.: PC-35488Not For Human Use, Lab Use Only.

GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism.
    GAT-100 is a covalent probe for mapping structure-function correlates characteristic of the druggable CB1R allosteric space.

    Physicochemical Properties

    M.Wt 432.59
    Formula C25H28N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-Ethyl-5-isothiocyanato-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

    References

    1. Kulkarni PM, et al. J Med Chem. 2016 Jan 14;59(1):44-60.

    2. Laprairie RB, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):776-98.

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