GB1874 | Beta-catenin-TCF4 inhibitor | Probechem Biochemicals

Chemical Structure : GB1874

CAS No.: 1011440-46-2

GB1874 (GB 1874, GB-1874)

Catalog No.: PC-73231Not For Human Use, Lab Use Only.

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.

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5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$588	In stock
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Biological Activity

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.
GB1874 affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro.
GB1874 inhibited the growth of CRC tumor xenografts in vivo.

Physicochemical Properties

M.Wt	421.559
Formula	C24H27N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-((4-ethylphenoxy)methyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl)thio)cyclopentan-1-one

References

1. Yannick D Benoit, et al. Cell Chem Biol. 2021 Oct 21;28(10):1394-1406.e10.

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GB1874 (GB 1874, GB-1874)

Biological Activity

Physicochemical Properties

References

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