GC-78-HCl

Chemical Structure : GC-78-HCl

Catalog No.: PC-21451Not For Human Use, Lab Use Only.

GC-78-HCl is a potent nonpeptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.19 uM, exhibits excellent antiviral activity (EC50=0.4 uM).

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Biological Activity

GC-78-HCl is a potent nonpeptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.19 uM, exhibits excellent antiviral activity (EC50=0.4 uM).
GC-78-HCl displays potent antiviral activities against various SARS-CoV-2 variants as well as HCoV-OC43 and HCoV-229E, indicating its potential broad-spectrum anticoronaviral activity.

Physicochemical Properties

M.Wt	551.85
Formula	C25H25Cl3N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(3,4-dichlorophenyl)-4-(4-methoxynicotinoyl)-N-(4-methoxyphenyl)piperazine-2-carboxamide hydrochloride

References

1. Shenghua Gao, et al. Journal of Medicinal Chemistry 2023

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GC-78-HCl

Biological Activity

Physicochemical Properties

References

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