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GCS-11

Chemical Structure : GCS-11

CAS No.:

GCS-11 (GCS11)

Catalog No.: PC-22754Not For Human Use, Lab Use Only.

GCS-11 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GCS-11 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities.

Physicochemical Properties

M.Wt 909.36
Formula C48H96N2O11S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((2S,3S,4R)-3,4-Dihydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadecan-2-yl)-11-(tridecylsulfonamido)undecanamide

References

1. Yu Wen, et al. J Med Chem. 2024 Jul 20. doi: 10.1021/acs.jmedchem.4c00782.

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