GCS-12 | NKT cell agonist | Probechem Biochemicals

Chemical Structure : GCS-12

GCS-12 (GCS12)

Catalog No.: PC-22755Not For Human Use, Lab Use Only.

GCS-12 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities.

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Biological Activity

Physicochemical Properties

M.Wt	909.36
Formula	C48H96N2O11S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,3S,4R)-3,4-Dihydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadecan-2-yl)-12-(dodecylsulfonamido)dodecanamide

References

1. Yu Wen, et al. J Med Chem. 2024 Jul 20. doi: 10.1021/acs.jmedchem.4c00782.

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GCS-12 (GCS12)

Biological Activity

Physicochemical Properties

References

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