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GDC-0339

Chemical Structure : GDC-0339

CAS No.: 1428569-85-0

GDC-0339 (GDC0339)

Catalog No.: PC-45110Not For Human Use, Lab Use Only.

GDC-0339 is a potent, orally bioavailable pan-Pim kinase inhibitor with Ki values of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GDC-0339 is a potent, orally bioavailable pan-Pim kinase inhibitor with Ki values of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively.

Physicochemical Properties

M.Wt 465.4952
Formula C20H22F3N7OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 52 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)-

References

1. Takahashi RH, et al. Drug Metab Dispos. 2017 Aug 8. pii: dmd.117.076786.

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