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Chemical Structure : GFB-12811
Catalog No.: PC-72894Not For Human Use, Lab Use Only.
GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.
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GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.
GFB-12811 is highly selective (>100-fold) over other CDKs (CDK1/2/6/7/9).
GFB-12811 demonstrated CDK5 target engagement while avoiding anti-proliferative effects associated with inhibiting other CDKs in cellular assays.
GFB-12811 exhibite promising in vivo PK profiles, enabling the use as tool compounds for interrogating the role of CDK5 in autosomal dominant polycystic kidney disease (ADPKD) and other diseases.
| M.Wt | 449.454 | |
| Formula | C22H23F4N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daniels MH, et al. J Med Chem. 2022 Feb 24;65(4):3575-3596.
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