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GFB-12811

Chemical Structure : GFB-12811

CAS No.: 2775311-17-4

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GFB-12811 (GFB12811)

Catalog No.: PC-72894Not For Human Use, Lab Use Only.

GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.
    GFB-12811 is highly selective (>100-fold) over other CDKs (CDK1/2/6/7/9).
    GFB-12811 demonstrated CDK5 target engagement while avoiding anti-proliferative effects associated with inhibiting other CDKs in cellular assays.
    GFB-12811 exhibite promising in vivo PK profiles, enabling the use as tool compounds for interrogating the role of CDK5 in autosomal dominant polycystic kidney disease (ADPKD) and other diseases.

    Physicochemical Properties

    M.Wt 449.454
    Formula C22H23F4N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(7-((5-fluoro-2-(trifluoromethyl)pyridin-4-yl)amino)-1,6-naphthyridin-2-yl)-1-(1-methylpiperidin-4-yl)ethan-1-ol

    References

    1. Daniels MH, et al. J Med Chem. 2022 Feb 24;65(4):3575-3596.

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