GFRα2/GFRα23 inhibitor 16

Chemical Structure : GFRα2/GFRα23 inhibitor 16

Catalog No.: PC-22671Not For Human Use, Lab Use Only.

GFRα2/GFRα23 inhibitor 16 is a selective small moelcule inhibitor of glycosylphosphatidylinositol-anchored co-receptor GFRa2/GFRa3 with IC50 of 0.1/0.2 uM respectively, selective over RET.

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Biological Activity

GFRα2/GFRα23 inhibitor 16 is a selective small moelcule inhibitor of glycosylphosphatidylinositol-anchored co-receptor GFRa2/GFRa3 with IC50 of 0.1/0.2 uM respectively, selective over RET.

Physicochemical Properties

M.Wt	589.74
Formula	C36H39N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-cyclohexyl-N-methyl-2-(2-(3-(((R)-5-(2-(phenylamino)pyrimidin-5-yl)-2,3-dihydro-1H-inden-2-yl)oxy)phenyl)acetamido)acetamide

References

1. Shea L Johnson, et al. Bioorg Med Chem Lett. 2024 Jul 12:129889.

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