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GGTI-2147

Chemical Structure : GGTI-2147

CAS No.: 191102-87-1

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GGTI-2147 (GGTI2147)

Catalog No.: PC-62471Not For Human Use, Lab Use Only.

GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).
    GGTI-2147 inhibits glucose- and KCl-induced insulin secretion.
    GGTI-2147 inhibits Rac1 geranylgeranylation, down-regulates the expression of p65, and ameliorated the OGD/R-induced neuronal apoptosis.

    Physicochemical Properties

    M.Wt 470.6
    Formula C28H30N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    L-Leucine, N-[4-[(1H-imidazol-4-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester (9CI)

    References

    1. Vasudevan A, et al. J Med Chem. 1999 Apr 22;42(8):1333-40.

    2. Amin R, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.

    3. Gao S, et al. Neuropharmacology. 2016 Apr;103:44-56.

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