Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-GGTI-2147
GGTI-2147

Chemical Structure : GGTI-2147

CAS No.: 191102-87-1

Add to Favorites

GGTI-2147 (GGTI2147)

Catalog No.: PC-62471Not For Human Use, Lab Use Only.

GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).
    GGTI-2147 inhibits glucose- and KCl-induced insulin secretion.
    GGTI-2147 inhibits Rac1 geranylgeranylation, down-regulates the expression of p65, and ameliorated the OGD/R-induced neuronal apoptosis.

    Physicochemical Properties

    M.Wt 470.6
    Formula C28H30N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    L-Leucine, N-[4-[(1H-imidazol-4-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester (9CI)

    References

    1. Vasudevan A, et al. J Med Chem. 1999 Apr 22;42(8):1333-40.

    2. Amin R, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.

    3. Gao S, et al. Neuropharmacology. 2016 Apr;103:44-56.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: