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Chemical Structure : GGTI-2154
Catalog No.: PC-22627Not For Human Use, Lab Use Only.
GGTI-2154 is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.
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GGTI-2154 is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.
GGTI-2154 inhibits the processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, in tumors obtained from mice.
GGTI-2154 suppresses constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium.
| M.Wt | 420.51 | |
| Formula | C24H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26.
2. Sun J, et al. Cancer Res. 2003 Dec 15;63(24):8922-9.
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