Chemical Structure : GGTI-2154 hydrochloride
CAS No.:
478908-50-8
GGTI-2154 hydrochloride
(GGTI 2154 hydrochloride)
Catalog No.: PC-22628Not For Human Use, Lab Use Only.
GGTI-2154 hydrochloride is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GGTI-2154 hydrochloride is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.
GGTI-2154 inhibits the processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, in tumors obtained from mice.
GGTI-2154 suppresses constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium.
Physicochemical Properties
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M.Wt
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456.97
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Formula
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C24H29ClN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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L-Leucine, N-[[5-[(1H-imidazol-4-ylmethyl)amino]-2′-methyl[1,1′-biphenyl]-2-yl]carbonyl]-, monohydrochloride
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References
1. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26.
2. Sun J, et al. Cancer Res. 2003 Dec 15;63(24):8922-9.
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