Catalog No.: PC-62152Not For Human Use, Lab Use Only.
GGTI-2418 (GGTI 2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI-2418 (GGTI 2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI 2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM.
GGTI 2418 suppresses the growth of human breast tumors in nude mouse xenografts.
GGTI 2418 increases p27(Kip1) and induces significant regression of breast tumors.
