Catalog No.: PC-62153Not For Human Use, Lab Use Only.
GGTI-2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI-2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI-2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM.
GGTI-2418 suppresses the growth of human breast tumors in nude mouse xenografts.
GGTI-2418 increases p27(Kip1) and induces significant regression of breast tumors.
Physicochemical Properties
M.Wt
463.514
Formula
C23H30N5NaO4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
((S)-2-benzyl-4-((4-methyl-1H-imidazol-5-yl)methyl)-3-oxopiperazine-1-carbonyl)-L-leucine, sodium salt
References
1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.
2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.
