Catalog No.: PC-62473Not For Human Use, Lab Use Only.
GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.
GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.
GGTI-286 inhibits processing of the geranylgeranylated protein Rap1A.
GGTI-286 inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM.
GGTI-286 reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells.
GGTI-286 has significant antiproliferative effect in human malignant glioma cells.
