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GGTI298

Chemical Structure : GGTI298

CAS No.: 180977-44-0

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GGTI298 (GGTI-298;GGTI 298)

Catalog No.: PC-42281Not For Human Use, Lab Use Only.

GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).

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1 mg $88 In stock
5 mg $158 In stock
10 mg $238 In stock
25 mg $398 In stock
50 mg $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).
GGTI298 induces G0-G1 block and apoptosis in A549 cells.

Physicochemical Properties

M.Wt 479.63422
Formula C27H33N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

References

1. McGuire TF, et al. J Biol Chem. 1996 Nov 1;271(44):27402-7.

2. Miquel K, et al. Cancer Res. 1997 May 15;57(10):1846-50.

3. Vogt A, et al. J Biol Chem. 1997 Oct 24;272(43):27224-9.

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