Catalog No.: PC-73195Not For Human Use, Lab Use Only.
GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
GI 254023X displays >100-fold selectivity for ADAM10 over ADAM17 (TACE).
GI 254023X bolcks antibody-induced shedding of target antigens, increases specificity of targeted immunotherapy in vitro.
GI 254023X inhibits PACAP-induced shedding of RAGE in PAC1/RAGE cells.
GI 254023X remarkably inhibits the proliferation and induce the apoptosis of H929 cells.
