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Chemical Structure : GI254023X
CAS No.: 260264-93-5
Catalog No.: PC-73195Not For Human Use, Lab Use Only.
GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $98 | In stock | |
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 100 mg | Get quote |
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GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
GI 254023X displays >100-fold selectivity for ADAM10 over ADAM17 (TACE).
GI 254023X bolcks antibody-induced shedding of target antigens, increases specificity of targeted immunotherapy in vitro.
GI 254023X inhibits PACAP-induced shedding of RAGE in PAC1/RAGE cells.
GI 254023X remarkably inhibits the proliferation and induce the apoptosis of H929 cells.
| M.Wt | 391.51 | |
| Formula | C21H33N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-((S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-((S)-1-(N-hydroxyformamido)ethyl)-5-phenylpentanamide |
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1. Hundhausen C, et al. Blood. 2003 Aug 15;102(4):1186-95.
2. Budagian V, et al. J Biol Chem. 2004 Sep 24;279(39):40368-75.
3. Verena V Metz, et al. PLoS One.2012;7(7):e41823.
4. Eichenauer DA, et al. Cancer Res. 2007 Jan 1;67(1):332-8.
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