GIT1/β-Pix inhibitor 14-5-18

Chemical Structure : GIT1/β-Pix inhibitor 14-5-18

Catalog No.: PC-26308Not For Human Use, Lab Use Only.

GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis.

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Biological Activity

Physicochemical Properties

M.Wt	391.42
Formula	C23H21NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (1S,2R,3R,4S,E)-6-(furan-3-ylmethylene)-1'-methyl-2',5-dioxospiro[bicyclo[2.2.1]heptane-2,3'-indoline]-3-carboxylate

References

1. Jing Gu, et al. Nat Commun. 2022 Nov 23;13(1):7176.

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