GLPG2737 | CFTR corrector | Probechem Biochemicals

Chemical Structure : GLPG2737

GLPG2737 (GLPG-2737)

Catalog No.: PC-26905Not For Human Use, Lab Use Only.

GLPG2737 is a potent type 2 CFTR corrector with EC50 of 71 nM, rescues the trafficking of ΔF508 CFTR to the plasma membrane in epithelial cell line stably expressing ΔF508 CFTR.

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Biological Activity

GLPG2737 is a potent type 2 CFTR corrector with EC50 of 71 nM, rescues the trafficking of ΔF508 CFTR to the plasma membrane in epithelial cell line stably expressing ΔF508 CFTR.

Physicochemical Properties

M.Wt	613.75
Formula	C30H40FN7O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclobutyl-N-(N,N-dimethylsulfamoyl)-1-(4-fluorophenyl)-4-(4-methoxy-[1,4'-bipiperidin]-1'-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxamide

References

1. Pizzonero M, et al. J Med Chem. 2024 Apr 11;67(7):5216-5232.

2. van Koningsbruggen-Rietschel S, et al. J Cyst Fibros. 2020 Mar;19(2):292-298.

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GLPG2737 (GLPG-2737)

Biological Activity

Physicochemical Properties

References

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