Catalog No.: PC-72080Not For Human Use, Lab Use Only.
GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.
GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.
GMFBI.1 inhibits PKA mediated phosphorylation of hGMF-β substrate in vitro and is non-toxic at lower concentrations on astrocyte cultures, significantly suppresses GMF-β phosphorylation on Ser83 at 250ng/mL (1.68uM).
GMFBI.1 reduces p38MAPK phosphorylation and NFκB expression levels in GMF-β overexpressing LPS induced astrocytes in vitro.
GMFBI.1 inhibitor reversed EAE and suppressed the proinflammatory response in severely paralyzed EAE animals.
Physicochemical Properties
M.Wt
148.165
Formula
C8H8N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(1H-Indazol-4-yl)methanol
References
1. Jane Jose Vattathara, et al. Sci Rep. 2020 Mar 2;10(1):3790.
