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Chemical Structure : GNE-0946
Catalog No.: PC-22403Not For Human Use, Lab Use Only.
GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.
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GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.
GNE-0946 displays >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs.
| M.Wt | 460.79 | |
| Formula | C22H12ClF3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Benjamin P Fauber, et al. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.
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