GNE-0946 | RORγ inverse agonist | Probechem Biochemicals

Chemical Structure : GNE-0946

GNE-0946 (GNE0946)

Catalog No.: PC-22403Not For Human Use, Lab Use Only.

GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.

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Biological Activity

GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.
GNE-0946 displays >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs.

Physicochemical Properties

M.Wt	460.79
Formula	C22H12ClF3N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[3-[2-Chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]-2-hydroxybenzoic acid

References

1. Benjamin P Fauber, et al. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.

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GNE-0946 (GNE0946)

Biological Activity

Physicochemical Properties

References

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