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Chemical Structure : GNE-140 racemate
CAS No.: 1802977-61-2
Catalog No.: PC-42245Not For Human Use, Lab Use Only.
GNE-140 racemate is the racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively.
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|---|---|---|---|
| 5 mg | $148 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $848 | In stock | |
| 500 mg | Get quote |
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GNE-140 racemate is the racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively.
GNE-140 racemate displays no inhibition on malate MDH-1, MDH-2 (IC50>10 uM for both enzymes), and no appreciable inhibition against a panel of 301 kinases (<50% inhibition at 1 uM).
GNE-140 racemate perturbs glycolysis and inhibits proliferation in MIA PaCa-2 cells (IC50=0.43 uM), decreases glucose uptake (IC50=0.47 uM).
Pancreatic cell lines that utilize oxidative OXPHOS rather than glycolysis are inherently resistant to GNE-140, which can be resensitized to GNE-140 with the OXPHOS inhibitor phenformin.
| M.Wt | 499.0447 | |
| Formula | C25H23ClN2O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)- |
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1. Boudreau A, et al. Nat Chem Biol. 2016 Oct;12(10):779-86.
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