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Chemical Structure : GNE-207
Catalog No.: PC-60307Not For Human Use, Lab Use Only.
GNE-207 (GNE207) is a novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM.
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GNE-207 (GNE207) is a novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM.
GNE-207 displays >2,500-fold selectivity over BRD4.
GNE-207 suppresses Myc transcript levels in MV-4-11 cellular assays with EC50 of 18 nM.
GNE-207 exhibits a good pharmacokinetic profile.
| M.Wt | 510.598 | |
| Formula | C29H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lai KW, et al. Bioorg Med Chem Lett. 2018 Jan 1;28(1):15-23.
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