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Chemical Structure : GNE-272
CAS No.: 1936428-93-1
Catalog No.: PC-60305Not For Human Use, Lab Use Only.
GNE-272 (GNE272) potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-272 (GNE272) potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively.
GNE-272 displays high selectivity over BRD4 (1) and other BRDs (>10 uM).
GNE-272 shows antiproliferative effect in hematologic cancer cell lines and modulates MYC expression in vivo.
GNE-272 exhibits excellent in vivo PK and antitumor activity in an AML tumor model.
| M.Wt | 424.48 | |
| Formula | C22H25FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-(3-((2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone |
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1. Crawford TD, et al. J Med Chem. 2016 Dec 8;59(23):10549-10563.
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