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Chemical Structure : GNE-371
CAS No.: 1926986-36-8
Catalog No.: PC-35709Not For Human Use, Lab Use Only.
GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
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| 50 mg | Get quote | ||
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GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members.
GNE-371 (GNE371) is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM).
GNE-371 exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371.
| M.Wt | 431.496 | |
| Formula | C24H25N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-But-3-enyl-4-[1-methyl-6-(morpholine-4-carbonyl)-benzimidazol-4-yl]-1H-pyrrolo[2,3-c]pyridin-7-one |
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1. Wang S, et al. J Med Chem. 2018 Oct 25;61(20):9301-9315.
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