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Chemical Structure : GNE-375
CAS No.: 1926989-06-1
Catalog No.: PC-62845Not For Human Use, Lab Use Only.
GNE-375 (GNE375) is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GNE-375 (GNE375) is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1.
GNE-375 decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance.
GNE-375 shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors.
| M.Wt | 451.523 | |
| Formula | C25H29N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-6-(but-2-en-1-yl)-4-(2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl)-2-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one |
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1. Crawford TD, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541.
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