GNE-502 | ER antagonist | Probechem Biochemicals

Chemical Structure : GNE-502

Catalog No.: PC-72665Not For Human Use, Lab Use Only.

GNE-502 (GNE502) is an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.

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Biological Activity

GNE-502 (GNE502) is an orally bioavailable and potent antagonist and degrader of the estrogen receptor protein.

M.Wt	471.591
Formula	C25H30FN3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3R)-1-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-methyl-2-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

1. Jason R Zbieg, et al. Bioorg Med Chem Lett. 2021 Oct 15;50:128335.